Poly(ethylene glycol) as solvent and polymer support in the microwave assisted parallel synthesis of aminoacid derivatives

A Schiff base protected glycine supported on a soluble polymer such as poly(ethylene glycol) reacted readily with various electrophiles in the presence of an inorganic base under microwave activation. It was shown in this study that the polymer support also serves as solvent in these reactions. Various α-aminoacids derivatives could be synthesized using this method.