Title of article :
Total synthesis of madindoline A
Author/Authors :
Hosokawa، نويسنده , , Seijiro and Sekiguchi، نويسنده , , Kazuhiko and Hayase، نويسنده , , Kanako and Hirukawa، نويسنده , , Yasushi and Kobayashi، نويسنده , , Susumu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The total synthesis of madindoline A was achieved. The key step of the synthesis is a reductive coupling of an acid-sensitive hydroxyfuroindoline derivative and a sterically hindered aldehyde using Sn(OTf)2–NaBH(OAc)3. After the reductive coupling, the derived trione was subjected to intramolecular condensation to construct a madindoline skeleton.
Keywords :
madindoline A , reductive coupling , tin(II) triflate , intramolecular condensation , total synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
