Title of article :
Expeditious N-monoalkylation of 1,4,7,10-tetraazacyclododecane (cyclen) via formamido protection
Author/Authors :
Boldrini، نويسنده , , Vincenzo and Giovenzana، نويسنده , , Giovanni B and Pagliarin، نويسنده , , Roberto and Palmisano، نويسنده , , Giovanni and Sisti، نويسنده , , Massimo، نويسنده ,
Abstract :
The reaction of cyclen 1 with chloral hydrate afforded exclusively 1,4,7-triformylcyclen 2 in high yield; the triprotected macrocycle was easily alkylated with various electrophiles in good to excellent yields. The alkaline removal of the formyl groups provided a selective entry into N-monosubstituted cyclen derivatives.
