Deprotection of N-tert-butoxycarbonyl (Boc) groups in the presence of tert-butyl esters
Author/Authors :
Lin، نويسنده , , Linus S and Lanza Jr.، نويسنده , , Thomas and de Laszlo، نويسنده , , Stephen E and Truong، نويسنده , , Quang and Kamenecka، نويسنده , , Theodore and Hagmann، نويسنده , , William K، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
4
From page :
7013
To page :
7016
Abstract :
Deprotection of Boc groups in the presence of tert-butyl esters was achieved by using concentrated H2SO4 (1.5–3.0 equiv.) in tBuOAc or MeSO3H (1.5–3.0 equiv.) in tBuOAc:CH2Cl2 (4:1 v/v). The yields ranged from 70 to 100% for a variety of amino acid and dipeptide substrates.
Keywords :
deblocking , amino acids and derivatives , protecting groups
