Author/Authors :
Pesenti، نويسنده , , Cristina and Arnone، نويسنده , , Alberto and Aubertin، نويسنده , , Anne Marie and Bravo، نويسنده , , Pierfrancesco and Frigerio، نويسنده , , Massimo and Panzeri، نويسنده , , Walter F. Schmidt، نويسنده , , Sylvie and Viani، نويسنده , , Fiorenza and Zanda *، نويسنده , , Matteo، نويسنده ,
Abstract :
The total synthesis of a trifluoromethyl (Tfm) analogue of the aspartate protease inhibitor Pepstatin has been accomplished via incorporation of two α-Tfm-amino β-hydroxy peptide isosteres instead of the natural statine units. The title compound as well as several Tfm-substituted precursors did not show anti-HIV activity.
Keywords :
peptide mimetics , Enzyme inhibitors , pepstatin , Trifluoromethyl group
