Title of article :
The squalestatins: tricyclic 3,4-β-lactone and 3,4-oxetane systems
Author/Authors :
Cox، نويسنده , , Brian and Morley، نويسنده , , Nicolas and Procopiou، نويسنده , , Panayiotis A and Sharratt، نويسنده , , Peter J and Watson، نويسنده , , Nigel S and Wild، نويسنده , , Deborah، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
Squalestatin 3,4-β-lactone-4,5-dimethyl ester (8) was reductively ring-opened to yield squalestatin 3-hydroxymethyl-4,5-dimethyl ester (6) using mild reducing conditions (sodium borohydride). Similarly, squalestatin 3,4-oxetane-4,5-dimethyl ester (10) was found to ring-open to 3-iodomethyl squalestatin (15) under the conditions used to cleave the methyl ester functions (lithium iodide/2,4,6-trimethylpyridine).
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
