Title of article
Enantioselective synthesis of the larger fragment of pamamycin-607
Author/Authors
Bernsmann، نويسنده , , Heiko and Gruner، نويسنده , , Margit and Metz، نويسنده , , Peter، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
7629
To page
7633
Abstract
The enantiomerically pure methyl ester of the complete larger hydroxy acid (C(1)C(18)) of the macrodiolide antibiotic pamamycin-607 has been synthesized using a general sultone route to actic acids and analogs. The requisite N,N-dimethylamino moiety was introduced by Mitsunobu inversion with hydrazoic acid followed by a reaction cascade involving hydrogenation and double reductive methylation.
Keywords
Mitsunobu reaction , antibiotics , sultones , Desulfurization
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1639100
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