Author/Authors :
Matsumura، نويسنده , , Ryuji and Suzuki، نويسنده , , Toshio J. Sato، نويسنده , , Kohki and Inotsume، نويسنده , , Takashi and Hagiwara، نويسنده , , Hisahiro and Hoshi، نويسنده , , Takashi and Kamat، نويسنده , , Vijayendra P and Ando، نويسنده , , Masayoshi، نويسنده ,
Abstract :
An efficient and versatile method for the stereospecific construction of α,ω-cis- and α,ω-trans-disubstituted oxepane skeletons is described. Cyclization of the hydroxy epoxides promoted by a (Bu3Sn)2O/Zn(OTf)2 system proceeded via an SN2 process and exo mode selectivity regardless of the configuration of the hydroxyl and the epoxy groups to provide the corresponding oxepanes in excellent yields.
Keywords :
epoxides , cyclization , regioselection , oxepanes
