Title of article
Novel and highly efficient DNA photocleavers: hydroperoxides of heterocyclic-fused naphthalimides
Author/Authors
Yao، نويسنده , , Wei and Qian، نويسنده , , Xuhong and Hu، نويسنده , , Qingyan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
7711
To page
7715
Abstract
A series of novel hydroperoxides of heterocyclic-fused naphthalimides were designed, synthesized and exhibited excellent DNA photonicking activities. Among these compounds, the benzothiophenonaphthalimide-type reagent proved to be the most efficient, it can induce single-strand nicks in duplex DNA at micromolar concentration upon illumination. The relationship between the molecular structure and cleaving activities was discussed.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1639140
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