Title of article :
Tryptophan-replacement and indole-modified apicidins: synthesis of potent and selective antiprotozoal agents
Author/Authors :
Colletti، نويسنده , , Steven L and Li، نويسنده , , Chunshi and Fisher، نويسنده , , Michael H and Wyvratt، نويسنده , , Matthew J and Meinke، نويسنده , , Peter T، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
5
From page :
7825
To page :
7829
Abstract :
A ruthenium tetraoxide catalyzed degradation of apicidinʹs tryptophan indole provided access to two useful carboxylic acid homolog intermediates. The synthesis of a series of potent and/or selective ketone homologs and 2-arylindoles derived from apicidin is described.
Keywords :
apicidin , Histone deacetylase , tryptophan analogs , selective
Journal title :
Tetrahedron Letters
Serial Year :
2000
Journal title :
Tetrahedron Letters
Record number :
1639194
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1639194
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