Author/Authors :
Meinke، نويسنده , , Peter T and Colletti، نويسنده , , Steven L and Ayer، نويسنده , , Michelle B and Darkin-Rattray، نويسنده , , Sandra J and Myers، نويسنده , , Robert W and Schmatz، نويسنده , , Dennis M and Wyvratt، نويسنده , , Matthew J and Fisher، نويسنده , , Michael H، نويسنده ,
Abstract :
An efficient degradation of apicidinʹs ketone-containing side chain to two common intermediates (the C7-aldehyde and the C8-methyl ester) is described. From these intermediates, a series of potent mechanism-based histone deacetylase inhibitors was prepared to facilitate biochemical studies.
Keywords :
apicidin , Inhibitor , trapoxin , Histone deacetylase , malaria , trichostatin
