Title of article
Reversible DNA photocircularization on triple helix: effect of vinyl substituent on base stacking
Author/Authors
Fujimoto، نويسنده , , Kenzo and Matsuda، نويسنده , , Shigeo and Hayashi، نويسنده , , Masayuki and Saito، نويسنده , , Isao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
7897
To page
7900
Abstract
An efficient method for the synthesis of circular oligodeoxyribonucleotides (ODNs) using reversible template-directed photoligation via 5-vinyldeoxycytidine (VC) is described. It is shown that the 5′-end VC of ODN reversibly reacts by photoirraditation with thymine at its own 3′-end in the presence of a single-stranded template via triple helix formation to produce circular DNA. Thermodynamic analysis indicated that the stability of triple helix is remarkably enhanced by the vinyl substituent of VC.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1639228
Link To Document