Author/Authors :
Rabanal، نويسنده , , Francesc and Pastor، نويسنده , , Jose J and Nicolلs، نويسنده , , Ernesto and Albericio، نويسنده , , Fernando and Giralt*، نويسنده , , Ernest، نويسنده ,
Abstract :
Aspartimide prone sequence containing protected peptides are successfully synthesized in solid phase by using the bifunctional linker N-[(9-hydroxymethyl)-2-fluorenyl] succinamic acid (HMFS) in combination with morpholine as the cleavage reagent. Access to high purity peptide synthons opens a straightforward way to the synthesis of large proteins by convergent strategies.
