Author/Authors :
Song، نويسنده , , Yuntao and Sercel، نويسنده , , Anthony D. and Johnson، نويسنده , , Don R. and Colbry، نويسنده , , Norman L. and Sun، نويسنده , , Kuai-Lin and Roth، نويسنده , , Bruce D.، نويسنده ,
Abstract :
Reactions of α-amino acids with ketones under hydrogenation conditions using 20% Pd(OH)2/C as the catalyst gave N-mono-alkylated amino acids in high yields. Reductive methylation of N-mono-alkylated amino acids under the same hydrogenation conditions at 50°C afforded N,N-di-alkylated amino acids in excellent yields. This simple method has been used to synthesize N-mono- and N,N-di-alkylated amino acids on a scale of 200 g.
Keywords :
Catalysis , Hydrogenation , amino acids and derivatives , Alkylation
