Title of article
Chirality transfer in the ene-reactions of 3-{2-(2S)-[2-(substituted)vinyl]pyrrolidin-1-yl}-2-(substituted)acrolein derivatives
Author/Authors
Noguchi، نويسنده , , Michihiko and Matsushita، نويسنده , , Ryo and Takamura، نويسنده , , Shinji and Uchida، نويسنده , , Takehiko and Kakehi، نويسنده , , Akikazu and Shiro، نويسنده , , Motoo and Yamamoto، نويسنده , , Hidetoshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
8489
To page
8493
Abstract
Ene-reactions of 3-{2-(2S)-[2-(substituted)vinyl]pyrrolidin-1-yl}-2-(substituted)acrolein derivatives 5, 8, 13, and 16 have been described. Carbonyl-ene reaction of 5 and 16 and imine-ene reaction of 8 proceeded in a highly selective manner to lead to azepine derivatives 6 and 17, and 9, respectively. The chirality of the starting acroleins was transferred almost perfectly to the azepine-ring through the ene reactions.
Keywords
azepines , Enantioselection , ene reactions , cyclization
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1639611
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