• Title of article

    Synthetic studies on the salicylihalamides: macrolactone formation via ring closing metathesis versus macrolactonization

  • Author/Authors

    Feutrill، نويسنده , , John T and Holloway، نويسنده , , Georgina A and Hilli، نويسنده , , Ferdows and Hügel، نويسنده , , Helmut M and Rizzacasa، نويسنده , , Mark A، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2000
  • Pages
    4
  • From page
    8569
  • To page
    8572
  • Abstract
    Two routes to the unusual 12-membered unsaturated benzolactone of the highly cytotoxic marine metabolites the salicylihalamides are presented. The first involves an RCM step to construct the C9C10 alkene bond and this provided the model macrolactones 9 and 10 in a ratio of 77:23, respectively. An alternative route involved a Stille coupling to construct the C8C9 bond followed by a macrolactonization to give the lactones 9 and 10 in a ratio of 96:4.
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2000
  • Journal title
    Tetrahedron Letters
  • Record number

    1639665

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1639665