Author/Authors :
Fava، نويسنده , , Cristiana and Galeazzi، نويسنده , , Roberta and Gonzalez-Rosende، نويسنده , , Eugenia Maria and Orena، نويسنده , , Mario، نويسنده ,
Abstract :
By treatment with methoxide anion on polymeric support (IRA 900), chiral β-oxo or β-sulphonylamides 2 bearing an α,β-unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions.
