Synthesis of symmetrical dimeric N,N′-linked peptides on solid support by olefin metathesis

A method has been developed for the synthesis of dimeric ligands of biological relevance on solid support using olefin metathesis as a key step. With the ruthenium catalyst used, the size of the peptide fragment did not influence the reaction. If the double bond involved was separated by at least ∼2 methylene groups from an amide group, products of good purity could be recovered.