Simultaneous detection of S and R captopril using sequential injection analysis

A simultaneous detection sequential injection analysis (SIA) system is proposed for the determination of S and R captopril using a potentiometric, enantioselective membrane electrode based on maltodextrin (DE=14–17) for the assay of S-captopril and an amperometric biosensor for the assay of R-captopril. The proposed SIA system can be utilized reliably for the on-line simultaneous detection of the enantiomers in the synthesis process at a rate of 38 samples per hour in the following linear concentration ranges: 100–1000 nmol/l (R-captopril) and 1–1000 μmol/l (S-captopril) with a RSD better than 0.009% (n=10).