Title of article :
A short and efficient synthesis of unnatural (R)-nicotine
Author/Authors :
Girard، نويسنده , , Sandrine and Robins، نويسنده , , Richard J and Villiéras، نويسنده , , Jean and Lebreton، نويسنده , , Jacques، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
A short and efficient synthesis of unnatural (R)-nicotine is described, in which the key step is an intramolecular hydroboration–cycloalkylation of an azido-olefin intermediate. The synthesis is achieved in only four steps, with an overall yield of 51% (or in six steps with an overall yield of 65%).
Keywords :
asymmetric synthesis , Alkaloids , allylation , boron and compounds , Azides
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
