Title of article
Stereoselective synthesis of optically active pyridyl alcohols via asymmetric transfer hydrogenation of pyridyl ketones
Author/Authors
Okano، نويسنده , , Kazuya and Murata، نويسنده , , Kunihiko and Ikariya، نويسنده , , Takao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
9277
To page
9280
Abstract
A chiral Ru(II) complex, RuCl[(S,S)-N-(p-toluenesulfonyl)-1,2-diphenyl-ethylenediamine](p-cymene), serves as an efficient catalyst for asymmetric transfer hydrogenation of 2-acetylpyridine with a substrate to catalyst molar ratio of 200–1000 with HCOOH as a hydrogen source to give (S)-1-(2-pyridyl)ethanol in an almost quantitative yield and with 95% ee.
Keywords
Asymmetric transfer hydrogenation , chiral Ru catalyst , Acetylpyridine , Formic acid
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1640145
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