Title of article
Design and synthesis of cyclic sialyl Lewis X mimetics: a remarkable enhancement of inhibition by pre-organizing all essential functional groups
Author/Authors
Tsai، نويسنده , , Chung-Ying and Huang، نويسنده , , Xuefei and Wong، نويسنده , , Chi-Huey، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
9499
To page
9503
Abstract
Two rigid macrocyclic glycopeptides 1 and 2 were designed to mimic the tetrasaccharide SLeX as inhibitors of P-selectin. While compound 1 was found to be 1000-fold more potent than SLeX with IC50=1 μM, compound 2 was not soluble in water for evaluation of its activity.
Keywords
mimetics , sialyl Lewis X , inhibition enhancement
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1640292
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