In pursuit of an anticancer vaccine: a monomolecular construct containing multiple carbohydrate antigens

The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Ley, and Tn tumor antigens clustered in a monomolecular array. In addition to being a realistic mimic of ‘micro-heterogeneous’ mucins, this class of vaccine may trigger a multifaceted immune response convergent on a particular cancer type.