Author/Authors :
Rougnon Glasson، نويسنده , , Sophie and Canet، نويسنده , , Jean-Louis and Troin، نويسنده , , Yves، نويسنده ,
Abstract :
An intramolecular Mannich reaction, involving various achiral aldehydes together with an α-chiral amine is employed as the key step for a stereocontrolled synthesis of highly substituted piperidine systems. Accordingly, 12 new piperidines bearing four asymmetric centers were prepared in six steps from commercial ketones.
