Title of article
Asymmetric Mn(III)-based radical synthesis of functionalized 2,3-dihydrofurans
Author/Authors
Garzino، نويسنده , , Frédéric and Méou، نويسنده , , Alain and Brun، نويسنده , , Pierre، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
9803
To page
9807
Abstract
The oxidative radical addition of alkyl acetoacetates to p-methoxycinnamoyl oxazolidinones promoted by Mn(III) has been studied. It only gives trans-disubstituted 2,3-dihydrofurans, with d.r. ranging from 2:1 to 9:1, depending on the substituent of the chiral auxiliary. After chromatographic separation of the two diastereomers, the oxazolidinone can be removed to afford enantiopure dihydrofuranyl esters in good overall yield.
Keywords
3-disubstituted dihydrofurans , optically active trans-2 , radical asymmetric synthesis , oxidative cyclization , Manganese(III) acetate
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1640490
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