Title of article
Efficient synthesis of primary amides using 2-mercaptopyridone-1-oxide-based uronium salts
Author/Authors
Bailén، نويسنده , , Miguel A. and Chinchilla، نويسنده , , Rafael and Dodsworth، نويسنده , , David J. and Nلjera، نويسنده , , Carmen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
9809
To page
9813
Abstract
S-(1-Oxido-2-pyridinyl)-1,1,3,3-tetramethylthiouronium tetrafluoroborate (TOTT) and hexafluorophosphate (HOTT) are cheap and convenient reagents for the rapid and high-yielding preparation of primary amides when reacted with carboxylic acids and ammonium chloride in the presence of diisopropylethylamine. The reaction is chemoselective and undesired ammonolysis of other sensitive functional groups is not observed.
Keywords
primary amides , Coupling reagents , aminium salts
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1640494
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