Author/Authors :
Takabe، نويسنده , , Kunihiko and Suzuki، نويسنده , , Masahisa and Nishi، نويسنده , , Toshiki and Hiyoshi، نويسنده , , Masaomi and Takamori، نويسنده , , Yasuaki and Yoda، نويسنده , , Hidemi and Mase، نويسنده , , Nobuyuki، نويسنده ,
Abstract :
High enantioselectivity was achieved in the lipase-catalyzed kinetic resolution of 5-hydroxypyrrolidin-2-one and 5-hydroxy-1,5-dihydropyrrol-2-one derivatives. Lipase PS and Novozym 435 were the successful catalysts (E=>1000). The acetylation of the N-protected 5-hydroxy-1,5-dihydropyrrol-2-one derivative gave the (R)-acetate with high enantioselectivity, while, without N-protection, the (S)-acetate was obtained.
