Title of article
Two novel pyrrole-imidazole alkaloids from the Mediterranean sponge Agelas oroides
Author/Authors
Fattorusso، نويسنده , , Ernesto and Taglialatela-Scafati، نويسنده , , Orazio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
6
From page
9917
To page
9922
Abstract
The novel pyrrole-imidazole alkaloids cyclooroidin (7) and taurodispacamide A (8) have been isolated from the Mediterranean sponge Agelas oroides, and their structures established from spectroscopic data. Although both these alkaloids may be conceived as derivatives of the C11N5 skeleton of the known oroidin (1), remarkably cyclooroidin (7) possesses the unprecedented N1/C9 connection. Taurodispacamide A (8) exhibited a good antihistaminic activity, tested on the isolated guinea pig ileum.
Keywords
Biologically active compounds , Marine metabolites , Alkaloids , Stereochemistry
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1640574
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