Title of article
A novel synthesis of 4′-thionucleosides and a potential stereospecific route to pyrimidine nucleosides
Author/Authors
Miller، نويسنده , , J.Allen and Pugh، نويسنده , , Ashley W and Ullah، نويسنده , , G.Mustafa and Gutteridge، نويسنده , , Clare، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
7
From page
10099
To page
10105
Abstract
Starting with the l-ascorbate derived epoxide 1, a di-t-butyl dithioacetal cyclisation route to 2′-deoxy-4′-thionucleosides has been developed. Based on an intermediate in this route, a novel and stereospecific route to α- or β-pyrimidine nucleosides has been conceived, but its implementation failed at a key ring-closure step.
Keywords
Epoxide opening , 2?-deoxy-4?-thionucleoside synthesis , di-t-butyl dithioacetal cyclisation
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1640689
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