Title of article
A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepines
Author/Authors
Anwar، نويسنده , , Balques and Grimsey، نويسنده , , Paul and Hemming، نويسنده , , Karl and Krajniewski، نويسنده , , Matthew and Loukou، نويسنده , , Christina، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
10107
To page
10110
Abstract
A new approach to the synthesis of imine containing 1,2,5-benzothiadiazepine-1,1-dioxides and 1,4-benzodiazepin-5-ones using iminophosphoranyl thiazine-S-oxides as precursors is reported. Key steps include a Staudinger reaction, an aza-Wittig reaction and the conversion of a thiazine-S-oxide into an amino ketone via a [2,3] sigmatropic rearrangement.
Keywords
benzodiazepines , benzothiadiazepines , thiazine-S-oxides , Aza-Wittig reaction
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1640693
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