Author/Authors :
Suzuki، نويسنده , , Toshio and Matsumura، نويسنده , , Ryuji and Oku، نويسنده , , Ken-ichi and Taguchi، نويسنده , , Keiichi and Hagiwara، نويسنده , , Hisahiro and Hoshi، نويسنده , , Takashi and Ando، نويسنده , , Masayoshi، نويسنده ,
Abstract :
The stereoselective formal synthesis of (+)-isolaurepinnacin is described. The required key oxepene skeleton possessing cis-oriented alkyl substituents at the α,ω-positions was stereoselectively constructed via the cyclization of the corresponding hydroxy epoxide promoted by the (Bu3Sn)2O/Zn(OTf)2 system.
Keywords :
natural products , oxepanes , medium-ring heterocycles , cyclization
