Title of article
Amine-catalyzed direct asymmetric Mannich-type reactions
Author/Authors
Notz، نويسنده , , Wolfgang and Sakthivel، نويسنده , , Kandasamy and Bui، نويسنده , , Tommy and Zhong، نويسنده , , Guofu and Barbas III، نويسنده , , Carlos F، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
199
To page
201
Abstract
Three chiral cyclic secondary amines are shown to be catalysts for the direct asymmetric Mannich-type reaction of acetone with a variety of preformed aldimines derived from o-anisidine. A simple one-pot three-component reaction procedure consisting of aldehyde, acetone, p-anisidine and an amine catalyst provides the corresponding β-amino ketones with 50–89% ee under very mild conditions.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641010
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