Title of article
Synthesis and reactivity of (1S)-N-(1-phenylethyl)maleimide towards nucleophiles: an application to preparation of chiral pyrroloisothiochroman and pyrrolobenzo[d]thiepine based on π-cationic cyclization
Author/Authors
K. Chihabeddine، نويسنده , , Abderrahim and Da??ch، نويسنده , , Adam and Jilale، نويسنده , , Abderrahim and Decroix، نويسنده , , Bernard، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
573
To page
576
Abstract
Chiral pyrroloisothiochroman and pyrrolo[d]thiepine were obtained efficiently in four steps from N-alkylated maleimides via, successively, sulfurization, regioselective reduction followed by π-cationic cyclization of the N-acyliminium ion intermediates. These latter, in addition, led to conjugate enamides as a consequence of the dehydration reaction.
Keywords
N-acyliminium ion , ?-cationic cyclization , aza-compounds , isothiochroman
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641309
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