Author/Authors :
Aiguade، نويسنده , , Josep and Hao، نويسنده , , Junliang and Forsyth، نويسنده , , Craig J، نويسنده ,
Abstract :
An acyclic intermediate representing a putative biomimetic precursor of the C28–C40 domain of the novel marine toxin azaspiracid was constructed convergently from C28–C34 and C35–C40 fragments. In studying the assembly of the C28–C34 dioxabicyclo[3.3.1]nonane system via an intramolecular hetero-conjugate addition upon a C34–C36 enone, a stereoselective C-Michael addition intervened to provide a highly substituted cyclohexane.
