Author/Authors :
Donohoe، نويسنده , , Timothy J and Winter، نويسنده , , Jonathan J.G and Helliwell، نويسنده , , Madeleine and Stemp، نويسنده , , Geoffrey، نويسنده ,
Abstract :
The regioselective dihydroxylation of a series of functionalised polyenes is described. Under acidic conditions, the osmate ester derivatives obtained from oxidation with OsO4/TMEDA undergo an intramolecular cyclisation reaction forming functionalised tetrahydrofurans with high stereoselectivity and in good yield. The generality of this method is illustrated with an application to the synthesis of a bis-tetrahydrofuran ring system.
