Author/Authors :
Ci، نويسنده , , Yun-xiang and Zhai، نويسنده , , Qi and Wang، نويسنده , , Shan and Chang، نويسنده , , Wen-bao and Zhang، نويسنده , , Chun-yang and Ma، نويسنده , , Hui and Chen، نويسنده , , Die-yan and Zhao، نويسنده , , Min-zheng and Hu، نويسنده , , Sheng-wen، نويسنده ,
Abstract :
In this paper, the voltammetric method was used for the first time to study the effect of Cisplatin-liposome on Hela cells. The results showed the voltammetric behavior of Hela cells was irreversible and the peak current had linear relationship with the cell number. With both Cisplatin-liposome concentration and treating time increasing, the peak current decreased. The peak current decreasing was in accordance with the nuclear damage and loss of mitochondrial membrane potential revealed by two-photon laser scanning microscopy and confocal laser scanning microscopy. This voltammetric method may provide a simple way to study the electron-transfer mechanism in drug-treating cells.
