Author/Authors :
Goetz، نويسنده , , Michael A and Zink، نويسنده , , Deborah L and Dezeny، نويسنده , , Gabe and Dombrowski، نويسنده , , Anne and Polishook، نويسنده , , Jon D and Felix، نويسنده , , John P and Slaughter، نويسنده , , Robert S and Singh، نويسنده , , Sheo B، نويسنده ,
Abstract :
The isolation, structure elucidation and chemical modification of nalanthalide, a novel diterpenoid pyrone blocker of the voltage-gated potassium channel Kv1.3 are reported. The structure–activity relationship of the derivatives with respect to various associated biological activities is also discussed.
