Author/Authors :
Fuchi، نويسنده , , Nobuhiro and Doi، نويسنده , , Takayuki and Harada، نويسنده , , Takeo and Urban، نويسنده , , Jan and Cao، نويسنده , , Bolong and Kahn، نويسنده , , Michael and Takahashi، نويسنده , , Takashi، نويسنده ,
Abstract :
We have developed a practical synthetic route to constrained β-strand mimetic templates by regioselective 1,3-dipolar cycloaddition of azomethine imines with vinyl sulfone. A small library of β-strand mimetic templates was generated which include potent and selective inhibitors of serine proteases.
Keywords :
Serine protease inhibitor , 1 , 3-dipolar cycloaddition , vinyl sulfone , Peptidomimetics
