Title of article
The synthesis of β-strand mimetic templates via regioselective 1,3-dipolar cycloaddition with vinylsulfone
Author/Authors
Fuchi، نويسنده , , Nobuhiro and Doi، نويسنده , , Takayuki and Harada، نويسنده , , Takeo and Urban، نويسنده , , Jan and Cao، نويسنده , , Bolong and Kahn، نويسنده , , Michael and Takahashi، نويسنده , , Takashi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
1305
To page
1308
Abstract
We have developed a practical synthetic route to constrained β-strand mimetic templates by regioselective 1,3-dipolar cycloaddition of azomethine imines with vinyl sulfone. A small library of β-strand mimetic templates was generated which include potent and selective inhibitors of serine proteases.
Keywords
Serine protease inhibitor , 1 , 3-dipolar cycloaddition , vinyl sulfone , Peptidomimetics
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641949
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