Title of article
Trifluoromethyl ketones derived from squalene: inhibition of the cholesterol biosynthesis in HepG2 cells
Author/Authors
Benayoud، نويسنده , , Farid and Abouabdellah، نويسنده , , Ahmed and Richard، نويسنده , , Cyrille and Bonnet-Delpon، نويسنده , , Danièle and Bégué، نويسنده , , Jean-Pierre and Levasseur، نويسنده , , Danielle and Boutaud، نويسنده , , Olivier and Schuber، نويسنده , , Francis، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
6367
To page
6370
Abstract
Trifluoromethyl ketones 1 and 2, have been prepared from trisnorsqualene aldehyde 3. These compounds and their corresponding alcohols 4 and 7 have been found to be good inhibitors of the biosynthesis of cholesterol in HepG2 cells. The inhibition is correlated with a decrease of the HMG-CoA reductase activity, probably resulting from the transformation of the fluorinated compounds into their corresponding oxysterols which could act as repressors of that enzyme.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1642246
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