Author/Authors :
Hubler، نويسنده , , Francis and Rückle، نويسنده , , Thomas and Patiny، نويسنده , , Luc and Muamba، نويسنده , , Tshilolo and Guichou، نويسنده , , Jean-François and Mutter، نويسنده , , Manfred and Wenger، نويسنده , , Roland، نويسنده ,
Abstract :
An efficient synthesis in 10 steps and overall yields up to 27% of NEtXaa4-cyclosporin A derivatives (Xaa=Leu, Val, Ile, Thr) starting from cyclosporin A is described. Biological activities of the new analogues show promising results for the design of cyclosporin derivatives exhibiting non-immunosuppressive and anti-HIV activity.
