Author/Authors :
Hu، نويسنده , , Youhong and Meuillet، نويسنده , , Emmanuelle J and Qiao، نويسنده , , Lixin and Berggren، نويسنده , , Margaret M and Powis، نويسنده , , Garth and Kozikowski، نويسنده , , Alan P، نويسنده ,
Abstract :
1d-3,4-Dideoxyphosphatidylinositol ether lipid 2, a PI analog, was synthesized through a sequence of protection/deprotection protocols and two Barton deoxygenation reactions, starting from l-(−)-quebrachitol. DDPIEL is 18-fold more potent than its monodeoxy counterpart DPIEL in the inhibition of PI3-K.
