Author/Authors :
Garc??a، نويسنده , , Eva and Arrasate، نويسنده , , Sonia and Ardeo، نويسنده , , Ainhoa and Lete، نويسنده , , Esther and Sotomayor، نويسنده , , Nuria، نويسنده ,
Abstract :
Stereocontrolled N-acyliminium ion cyclisation of L-DOPA derived succinimide 5 has been investigated. Addition of organolithiums to chiral non-racemic 5 yields oxoamides, which are cyclised diastereoselectively upon treatment with BF3·OEt2, to afford 5,10b-trans pyrroloisoquinolones in moderate yields and high ee (99%).
