Regioselective alkylation of guanines using 2-acetoxytetrahydrofurans
Author/Authors :
Geen، نويسنده , , Graham R and Kincey، نويسنده , , Peter M and Spoors، نويسنده , , P.Grant، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Pages :
4
From page :
1781
To page :
1784
Abstract :
Reaction of silylated guanine derivatives with 2-acetoxy-4-benzoyloxymethyltetrahydrofuran in DMF or NMP resulted in selective N-9 alkylation. This was used as the basis for a regioselective synthesis of the anti-viral agents famciclovir and penciclovir.
