Title of article
Stereoselective synthesis of 3-substituted phtalides via asymmetric transfer hydrogenation using well-defined ruthenium catalysts under neutral conditions
Author/Authors
Patricia Everaere، نويسنده , , Kathelyne and Scheffler، نويسنده , , Jean-Luc and Mortreux، نويسنده , , André C. Carpentier، نويسنده , , Jean-François، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
1899
To page
1901
Abstract
The asymmetric transfer hydrogenation of methyl 2-acylbenzoates and 2-propyl 3-acetylpyridine-2-carboxylate in 2-propanol, in the absence of base, with presynthesized Ru-{β-amino alcohol) or Ru-{TsDPEN} true catalysts provides 3-alkylphtalides in high yields and 92–97% ee. The procedure is, however, not as efficient for the preparation of optically active 3-phenylphtalide.
Keywords
Asymmetric transfer hydrogenation , chiral phtalides , chiral Ru catalysts
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1643577
Link To Document