Wondonins A and B, new bis(dihydroxystyryl)imidazoles from a two-sponge association

Wondonins A and B, two alkaloids of an unprecedented structural class, along with the previously described dihydroxystyryl sulfates, have been isolated from an association of the sponges Poecillastra wondoensis and Jaspis sp. collected from Keomun Island, Korea. The structures of these compounds have been determined as imidazole alkaloids containing a bis(dihydroxystyrene) moiety by combined spectroscopic methods. The new compounds exhibited antiangiogenic activity against human umbilical vein endothelial cells.