2-Polystyrylsulfonyl ethanol supports for the solid-phase syntheses of hydantoins and ureas

Reaction of sodium polystyrylsulfinate 1 with 2-chloroethanol gave the 2-arylsulfonyl ethanol resin 2, which was converted to the polymer-supported amine 5. Amine 5 was coupled with an isocyanate or an isothiocyanate to give the polymer-supported urea derivatives 6. Treatment of the resin 6 with 6N HCl gave hydantoins 7, while reaction of the same resin with 4N NaOH then HCl gave the urea derivatives 8.