Polycyclitols: synthesis of novel carbasugar and conduritol analogues as potential glycosidase inhibitors

Stereoselective syntheses of a new family of hydrindane based bicyclitols with seven hydroxyl groups in a diverse stereochemical array have been accomplished from readily available building-blocks. One of the bicyclitols 12 has been found to exhibit moderate α-glucosidase inhibitory activity in enzymatic assays.