Evaluation of titanium alkoxides and aryloxides in the Kulinkovich cyclopropanation of carboxylic esters

Systematic evaluation of several titanium alkoxides and aryloxides was undertaken in the titanium-mediated cyclopropanation reactions of carboxylic esters. Chlorotitanium triisopropoxide and/or methyltitanium triisopropoxide were found to be the reagents of choice for the olefin exchange modification, whereas the original Kulinkovich process proved to be insensitive to the nature of titanium alkoxides and aryloxides.