Title of article :
A Dde-based carboxy linker for solid-phase synthesis
Author/Authors :
Chhabra، نويسنده , , Siri Ram and Parekh، نويسنده , , Harendra and Khan، نويسنده , , Azra N and Bycroft، نويسنده , , Barrie W and Kellam، نويسنده , , Barrie، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
The Dde-derived carboxy protecting group, 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester (ODmab) has been developed into a carboxy functional linker. The stability of the linker to standard acid and base conditions employed in Fmoc/tBu SPPS has been demonstrated and its utility illustrated by the construction of model peptides, Leu-enkephalin and Human Angiotensin II.
Keywords :
carboxylic acids , solid-phase synthesis , supported reagents/reactions , linkers
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
