Author/Authors :
Takamatsu، نويسنده , , Satoshi and Maruyama، نويسنده , , Tokumi and Katayama، نويسنده , , Satoshi and Hirose، نويسنده , , Naoko and Naito، نويسنده , , Masaki and Izawa، نويسنده , , Kunisuke، نويسنده ,
Abstract :
A practical synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (1, FddA) via a 6-chloro-9-(3-deoxy-β-d-erythro-pentofuranosyl)-9H-purine (6) is described. Fluorination at the C2′-β position of the purine 3′-deoxynucleoside was improved by the introduction of 6-chloro group, and proceeded in moderate yield. The total yield of FddA from readily available starting material 6 was 35%.
